Background: This study aimed to identify the risk factors related in recurrence with isolated intra-abdominal lymph node metastasis in patients with colorectal cancer. Methods: This is a retrospective, cross-sectional study of 21 colorectal cancer patients with isolated intra-abdominal lymph node metastases. Preoperative demographic and laboratory/postoperative histological features of these patients were been analyzed. Results: Lymphovascular and perineural invasion and mutant-type K-ras status were more common in the study patients. In addition, a significant correlation was been detected between lymphovascular and perineural invasion, preoperative serum CEA level, preoperative thrombocyte count, mutant-type K-ras status, and pathological N3 disease. Mutant-type K-ras status and the presence of lymphovascular invasion were independent prognostic risk factors for isolated intra-abdominal lymph node metastasis. Conclusions: The presence of lymphovascular invasion and mutant-type K-ras status may be poor prognostic risk factors for isolated intra-abdominal lymph node metastasis in patients with colorectal cancer. However, studies involving larger patient series, molecular indicators, and cohorts with metastasis in other areas are been needed to verify this study.