ISSN: 2651-4532 / E-ISSN: 2452-3364

JOURNAL of
ONCOLOGICAL
SCIENCES
REVIEW ARTICLE
Immunotherapy for Lung Cancer
Received Date : 05 Aug 2022
Accepted Date : 11 May 2023
Available Online : 07 Jun 2023
Abstract Full PDF Similar Articles
Nuri KARADURMUŞa, Nalan AKYÜREKb, Adnan AYDINERc, Recep SAVAŞd, Özlem SÖNMEZe, Mehmet Ali Nahit ŞENDURf, Başak OYANe, Deniz YALMANg, Mehmet Ufuk YILMAZh, Ülkü YILMAZi, Perran Fulden YUMUKj, Erdem GÖKERk
aDepartment of Medical Oncology, University of Health Sciences Gülhane Training and Research Hospital, Ankara, Türkiye bDepartment of Pathology, Gazi University School of Medicine, Ankara, Türkiye cDepartment of Medical Oncology, İstanbul University Institute of Oncology, İstanbul, Türkiye dDepartment of Radiology, Ege University Faculty of Medicine, İzmir, Türkiye eDepartment of Medical Oncology, Acıbadem University Faculty of Medicine, İstanbul, Türkiye fDepartment of Medical Oncology, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Türkiye gDepartment of Radiation Oncology, Ege University Faculty of Medicine, İzmir, Türkiye hDepartment of Chest Diseases, University of Health Sciences, Dr. Suat Seren Chest Diseases and Surgery Training and Research Hospital, İzmir, Türkiye iDepartment of Chest Diseases, University of Health Sciences, Atatürk Chest Diseases and Surgery Training and Research Hospital, Ankara, Türkiye jDivision of Medical Oncology, Koç University Hospital, İstanbul, Türkiye kDepartment of Medical Oncology, Ege University Faculty of Medicine, İzmir, Türkiye
Doi: 10.37047/jos.2022-92712 - Article's Language: EN
J Oncol Sci. 2023;9(2):97-111
This is an open access article under the CC BY-NC-ND license
ABSTRACT
Lung cancer is one of the leading causes of cancer-related deaths in men and women. Similar to the approach with other cancer types, lung cancer staging is crucial in planning an effective treatment plan and predicting patient prognosis. Effective immunotherapies for patients with non-small cell lung cancer and non-genomic driver mutations are rapidly evolving. Moreover, anti-programmed death receptor- 1 (PD-1)/programmed death ligand 1 (PD-L1)-based treatments have become the first-line standard of care. Despite shortcomings, PD-L1 expression level seems currently to be a relatively reliable predictor of the clinical efficacy of treatment with anti-PD-1/PD-L1 antibodies. However, additional biomarkers are required to better personalize treatment options for these patients. This review aimed to increase awareness of lung cancer and immunotherapy treatment options, depending on patient and disease stage characteristics.
Keywords: Biomarker; immune checkpoint inhibitor; immunotherapy; mutation; non-small cell lung cancer
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