JOURNAL of
ONCOLOGICAL
SCIENCES

CASE REPORT

Breast Cancer Metastasis to Nasal Septum
Received Date : 25 Nov 2022
Accepted Date : 05 Jul 2023
Available Online : 20 Jul 2023
Doi: 10.37047/jos.2022-94489 - Article's Language: EN
J Oncol Sci.Journal of Oncological Sciences. 2023;9(3):181-3.
This is an open access article under the CC BY-NC-ND license
ABSTRACT
Approximately 4% of the patients present with distant metastasis in breast cancer at the time of presentation, with many more developing the distant disease subsequently. A rare site for metastases is the head and neck. Herein, we present a case of nasal septum metastasis from breast cancer. A female patient presented with a mass in the right breast with the diagnosis of breast cancer. She presented with bilateral pulmonary and bony lesions, after 2 years of follow-up. Vinorelbine therapy was continued, and the patient presented with refractory epistaxis. On physical examination, a reddish and fragile mass in the left nasal cavity was detected. Bleeding was controlled using compressive measures. The excisional biopsy revealed invasive ductal carcinoma metastasis. Breast cancer metastasis to the nasal cavity is extremely rare. Clinicians should consider metastasis in cases of treatment-resistant epistaxis, nasal obstruction, and visual impairment.
REFERENCES
  1. Diaby V, Tawk R, Sanogo V, Xiao H, Montero AJ. A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer. Breast Cancer Res Treat. 2015;151(1):27-40. [Crossref]  [PubMed]  [PMC] 
  2. Dietl B, Marienhagen J, Schaefer C, Pohl F, Kölbl O. [Frequency and distribution pattern of distant metastases in patients with ENT tumors and their consequences for pretherapeutic staging]. Strahlenther Onkol. 2007;183(3):138-143. [Crossref]  [PubMed] 
  3. Tracy JC, Mildenhall NR, Wein RO, O'Leary MA. Breast cancer metastases to the head and neck: case series and literature review. Ear Nose Throat J. 2017;96(3):E21-E24. [Crossref]  [PubMed] 
  4. Allen A, Michals E, Karo A, Loeffler DM, Saran N. Renal cell carcinoma presenting as epistaxis from a nasal cavity metastasis. Radiol Case Rep. 2018;14(1):116-120. [Crossref]  [PubMed]  [PMC] 
  5. Bastier PL, Dunion D, de Bonnecaze G, Serrano E, de Gabory L. Renal cell carcinoma metastatic to the sinonasal cavity: a review and report of 8 cases. Ear Nose Throat J. 2018;97(9):E6-E12. [Crossref]  [PubMed] 
  6. Prescher A, Brors D. [Metastases to the paranasal sinuses: case report and review of the literature]. Laryngorhinootologie. 2001;80(10):583-594. [Crossref]  [PubMed] 
  7. Agrawal S, Jayant K. Breast cancer with metastasis to the nasopharynx and paranasal sinuses. Breast J. 2016;22(4):476-477. [Crossref]  [PubMed] 
  8. Copson B, Pratap U, McLean C, Hayes T. Nasopharyngeal metastasis of breast carcinoma with HER 2 discordance: a case report. ANZ J Surg. 2018;88(5):508-509. [Crossref]  [PubMed] 
  9. Weng B, Wang Q, Lin S, Lu Y. Nasal cavity metastasis of breast cancer: a case report and review of the literature. Int J Clin Exp Pathol. 2014;7(10):7028-7033. [PubMed]  [PMC] 
  10. Vega LG, Dipasquale J, Gutta R. Head and neck manifestations of distant carcinomas. Oral Maxillofac Surg Clin North Am. 2008;20(4):609-623. [Crossref]  [PubMed] 
  11. Liao HS, Hsueh C, Chen SC, Chen IH, Liao CT, Huang SF. Solitary nasal cavity metastasis of breast cancer. Breast J. 2010;16(3):321-322. [Crossref]  [PubMed] 
  12. Özgür E. ÜH, Jurlina M. Endoscopic management of malignant sinonasal tumours. In: Cingi C, Bayar Muluk N, eds. All Around the Nose Basic Science, Diseases and Surgical Management. 1st ed. Cham: Springer; 2020. p.635-41. [Crossref] 
  13. Luong A, Citardi MJ, Batra PS. Management of sinonasal malignant neoplasms: defining the role of endoscopy. Am J Rhinol Allergy. 2010;24(2):150-5. [Crossref]  [PubMed]